From I-90:
Take Exit 32 (Bayfront Connector). Continue on the Bayfront Connector to 12th St. Turn right heading East on 12th St. Continue approximately 1 mile and Penn Beer will be on your right.
From I-79:
Take I-79 to the Bayfront Connector (final exit on I-79 North). Continue on the Bayfront Connector to 12th St. Turn left heading East on 12th St. Continue approximately 1 mile and Penn Beer will be on your right.